Biology-on-Array

Find the mechanisms behind changes in gene expression with Biology-on-Array.

The Biology-on-Array systems identify pathways that regulate a phenotype by linking regulatory factors with associated gene expression changes. The system combines RNAi and qRT-PCR to yield a reverse genetic approach. Each Biology-on-Array system disrupts the function of a panel of relevant regulatory genes in parallel, and expression changes associated with the disruptions are then measured by Real-time PCR. The included Biology-on-Array analysis software simplifies the analysis and leads to mechanism discovery.

Biology-on-Array benefits:

• Researchers that want to determine which signaling pathways or transcription factors regulate changes in a gene's expression.
• Researchers that want to understand the mechanisms that control a set of biomarkers.

Biology-on-Array provides a comprehensive answer to biological mechanisms related to:

• Cancer
• Immunology
• Metabolic Disorders
• Stem Cell
• Stress Response
• Epigenetic Factors
• Nuclear Receptors
• Complete Set of 672 Transcription Factors

For more information about how to use the Biology-on-Array Systems:

Read how Biology-on-Array was used to identify the pathways regulating the cellular response to a chemotherapeutic drug.
Application Example

For a detailed description of the protocol and other technical tips:
User Manual

For more information about the data analysis software:
Data Analysis

Biology-on-Array protocols use a reverse transfection. For users that need to optimize a reverse transfection, please see the Optimization System for Biology-on-Array:
Optimization System